SAN DIEGO -- Jason Marquis combined with four relievers on a four-hitter to win his fifth straight start, and Will Venable homered to lead the San Diego Padres to a 4-2 win against the NL Central-leading St. Louis Cardinals on Monday night.

Marquis (6-2) has won five consecutive starts for the first time since 2007 with the Chicago Cubs. He allowed two runs, one earned, on three hits in six innings while striking out three and walking four.

Chris Denorfia went 3 for 3 with an RBI for the Padres, who have won three straight and five of seven. Huston Street pitched the ninth for his 11th save in 12 chances.

Venable homered into the Jack Daniel's Old No. 7 Deck atop the right-field fence leading off the seventh, his seventh. It came on the second pitch from Mitchell Boggs, who just returned from a demotion to Class AAA Memphis.

The Padres chased St. Louis rookie Shelby Miller in the sixth, when they scored two runs on three walks, one hit and a hit batter.

With the Cardinals leading 2-1, manager Mike Matheny pulled Miller after his second walk of the inning, with two outs. Denorfia greeted Fernando Salas with an RBI single. John Baker walked to load the bases and Salas hit pinch-hitter Jesus Guzman with a pitch to bring in another run.

Miller (5-3) allowed three runs and five hits in 5 2/3 innings, struck out five and walked three.

He entered with a 1.40 ERA, tied with Clayton Kershaw of the Los Angeles Dodgers for the lowest in the majors. It went up to 1.74. Two starts earlier, Miller allowed a single to start the game and then retired the next 27 batters in a 3-0 home win against Colorado.

Miller's scoreless streak of 14 2/3 innings ended in the first when Everth Cabrera hit a leadoff single and scored on Chase Headley's one-out single.

The Cardinals tied it in the second when Headley, San Diego's Gold Glove third baseman, booted Miller's bases-loaded grounder for an error, allowing Yadier Molina to score. The Cardinals added a run in the third when Carlos Beltran hit a leadoff double, advanced on Matt Holliday's single and scored on Allen Craig's double-play grounder.

San Diego had a prime opportunity to score in its half when Cabrera hit a leadoff triple to right-center. But he was stranded when Miller struck out Will Venable and Headley before Carlos Quentin popped up.

Noteworthy

* Cardinals 3B David Freese was a late scratch due to getting three stitches in the base of his right thumb after getting spiked by Milwaukee's Norichika Aoki while tagging him out during a rundown Sunday. Freese was replaced by Ty Wigginton, who grew up in suburban Chula Vista.

* Marquis has a 2.27 ERA during his five-game winning streak.

* The series continues tonight when St. Louis RHP Adam Wainwright (5-3, 2.51 ERA) faces RHP Edinson Volquez (3-4, 5.55).