TORONTO -- Carlos Delgado sure woke up in a big way.

The Toronto slugger took cold medicine and a nap before the game, then hit four home runs Thursday night to become the 15th player in major league history to accomplish the feat

Delgado connected in all four of his at-bats, leading the Blue Jays over Tampa Bay 10-8. His first homer of the game was the 300th of his career.

"I can't think of any other way to explain it, it just kind of happened," he said. "It seems like everything you hit goes into the air and goes out. I wish I could do it more often."

Delgado was the first player to homer four times in a game since former Toronto teammate Shawn Green did it for Los Angeles on May 23, 2002, against Milwaukee.

Delgado was the fifth AL player to homer four times, the first since Mike Cameron for Seattle on May 2, 2002, against the Chicago White Sox.

Lou Gehrig, Rocky Colavito and Pat Seerey also did it in the AL.

Delgado's record-tying shot came leading off the eighth inning, a long drive to center field that tied it at 8.

Delgado flipped his bat and his teammates threw up their arms when he connected on a 2-2 pitch from Lance Carter to match the mark.

Delgado became the 98th player to reach 300 career homers with a three-run shot in the first inning.