This time, Carlos Beltran, David Freese and the St. Louis Cardinals took a six-run lead -- and held onto it, barely.

Beltran and Freese hit two-run homers and these wild, wild-card Cardinals beat the San Francisco Giants 6-4 on Sunday night in Game 1 of the NL championship series.

The defending World Series champions took an early 6-0 cushion and made it stand up. Only two nights earlier, the Cardinals came back from a 6-0 deficit, using a four-run rally in the ninth inning at Washington in the deciding Game 5 of the division series.

The St. Louis bullpen delivered 5 1/3 scoreless innings after starter Lance Lynn was chased. Edward Mujica, the fifth St. Louis pitcher, struck out the side in order in the seventh for the win. Jason Motte finished for his second save of the postseason.

The Cardinals gave first-year manager Mike Matheny a win against his former club.

St. Louis Cardinals' David Freese hits a two-run home run during the second inning of Game 1 of baseball's National League championship series against the San Francisco Giants Sunday, Oct. 14, 2012, in San Francisco. (AP Photo/Mark Humphrey)

Matheny's crew hardly looked road weary after a cross-country trip. The Giants dropped to 0-3 at home so far during these playoffs, outscored 20-6 at AT&T Park.

Game 2 in the best-of-seven series is tonight. Chris Carpenter pitches for the Cardinals against Ryan Vogelsong.

This is the first time the previous two World Series winners are facing off in the postseason since the 1958 World Series between the Braves and Yankees.

Beltran's fourth-inning drive into the seats in left-center chased San Francisco starter Madison Bumgarner, who has been a far cry from the impressive pitcher he was during the 2010 World Series run.

It was Beltran's 14th career postseason home run and third this October.

The Cardinals’ Carlos Beltran hits a two-run home run against the Giants during the fourth inning of Game 1 of the National League championship series Sunday in San Francisco. (Mark Humphrey ~ Associated Press)

Beltran spent the second half of the 2011 season with San Francisco after a trade from the Mets, but the Giants missed the playoffs last fall after the capturing an improbable championship a year earlier. The orange towel-waving sellout crowd of 42,534 let him have it with boos at every opportunity -- during pregame introductions and each time he stepped into the batter's box.

Both teams were well rested a day after a rough night of travel. The Giants barely beat the Cardinals to the Bay Area early Saturday after they were delayed three hours on the tarmac in Cincinnati on Friday night -- to refuel and for a mechanical problem after waiting out the Cardinals-Nationals game to know where they were headed next.

Matheny stuck with the same winning lineup that he sent out for Game 5, and some of the same faces came through again.

Daniel Descalso, who hit a tying, two-out single in Friday's 9-7 win, added two more hits with a double.

Descalso hit a one-out double in the fourth, then rookie Pete Kozma drove him home with a double of his own.

Giants starting pitcher Madison Bumgarner hands the ball to manager Bruce Bochy after being taken out of the game during the fourth inning. (Ben Margot ~ Associated Press)

The pair had also teamed up on the Nationals in the ninth inning Friday, with Kozma following Descalso with a go-ahead, two-run single.

Descalso shined playing in his native Northern California. He spends his offseasons in San Francisco's Marina district.

St. Louis 18-game winner Lynn didn't allow a hit until Marco Scutaro's single to left leading off the fourth. Hunter Pence singled two outs later and Brandon Belt drove him home with a single. Gregor Blanco followed with a two-run triple, then Brandon Crawford hit an RBI double. Pinch hitter Aubrey Huff -- a 2010 postseason star now in a diminished role -- drew a walk to cheers of "Aubrey! Aubrey!"

And, just like that, Lynn was done.

Bumgarner and Lynn each lasted only 3 2-3 innings. That made for a long night on both bullpens.

St. Louis Cardinals' Daniel Descalso (33) makes a play on a ball hit by San Francisco Giants' Angel Pagan during the fourth inning of Game 1 of baseball's National League championship series Sunday, Oct. 14, 2012, in San Francisco. (AP Photo/Eric Risberg)

The pressure is now on for the Giants not to fall behind 2-0 at home again. They lost the first two games of their division series here to the Reds last weekend before winning three in a row at Cincinnati. They went 48-33 at AT&T Park this season.

Bumgarner, a 16-game winner for the NL West champs, lost Game 2 of the division series at home to the Reds exactly a week earlier.

He pitched a 1-2-3 first on Sunday but ran into trouble in the second when Yadier Molina singled on an 0-2 pitch with one out. Freese then drove a 3-2 pitch over the wall in left-center to give the Cardinals a 2-0 lead.

Bumgarner needed 30 pitches to get through the second, and now has a 11.25 ERA in his two postseason starts this year.

Lynn returned to the rotation for the NLCS and his first career postseason start after making four relief appearances in the division series. Matheny needed another starter after left-hander Jaime Garcia injured his left shoulder in Game 2 against the Nationals.

NOTES: Matheny caught for the Giants in 2005-06. ... Freese's two RBIs gave him 25 for his postseason career, tied with Molina for third most on the Cardinals. Albert Pujols in No. 1 with 52, while Jim Edmonds has 41. ... Both teams kept their rosters intact from the division series. ... The clubs split their season series 3-all. ... Giants assistant batting coach Joe Lefebvre took over 1B coaching duties in place of Roberto Kelly, who sustained a concussion after being hit in the head while on the field during batting practice Saturday on a ball hit by Buster Posey. ... Matheny received a nice ovation during pregame introductions. ... More fans packed the viewing portwalk outside the ballpark beneath the right-field arcade.