SAN DIEGO -- Daniel Descalso hit his first career grand slam and had a career-high five RBIs, and Adam Wainwright won for the first time at Petco Park as the St. Louis Cardinals beat the San Diego Padres 10-2 Tuesday night.

Descalso lined a 1-2 pitch from Anthony Bass into the Jack Daniel's Old No. 7 Deck in right-center with one out in the eighth, his second homer of the season. Jon Jay was intentionally walked ahead of him.

Descalso, hitting just .197 coming in, went 3 for 3 with a walk and scored three runs. He missed the cycle by a triple. He singled leading off the third and scored on Matt Carpenter's double. He hit an RBI double in the four-run fifth and scored on Carlos Beltran's two-run single.

Matt Holliday struck out opening the eighth but reached on Bass' wild pitch, and Allen Craig singled. Padres first baseman Yonder Alonso tried for a reverse double play on Yadier Molina's grounder but his wide throw pulled shortstop Everth Cabrera off the bag and Craig was safe. Jay was intentionally walked, and Descalso hit his slam.

Wainwright (6-3) held San Diego to one run and four hits in 7 1-3 innings, struck out six and walked one.

The 6-foot-7 right-hander had been 0-2 with a 2.57 ERA in his previous three appearances at the spacious downtown ballpark, including two starts. That leaves New York's Citi Field as the only NL park where Wainwright has never earned a victory.

San Diego's Edinson Volquez (3-5) allowed five runs and eight hits in six innings, struck out five and walked one. He allowed four runs on six hits in the fifth.

San Diego got its only run in the second when rookie Jedd Gyorko doubled, advanced on Chris Denorfia's single and scored on Alexi Amarista's double play. Gyorko had three hits.

Noteworthy

* Cardinals 3B David Freese was out of the lineup for the second straight game. He got three stitches in the base of his right thumb after getting spiked by Milwaukee's Norichika Aoki while tagging him out during a rundown Sunday.

* Padres LF Carlos Quentin sat out with a balky right knee. He had an awkward slide into home in Monday night's 4-2 victory.

* The series concludes tonight when St. Louis LHP Tyler Lyons is scheduled to make his big league debut against rookie RHP Burch Smith (0-0, 15.63). Lyons will be the second Cardinals lefty in nine days (John Gast, May 4 vs. New York Mets) to make his big league debut in a start. Lyons was a ninth-round pick out of Oklahoma State in the 2010 draft.