Former U.S. Rep. Todd Akin, a conservative Missouri Republican whose comment that women’s bodies have a way of avoiding pregnancies in cases of “legitimate rape” sunk his bid for the U.S. Senate and became a cautionary tale for other GOP candidates, has died. He was 74.

Akin had cancer for several years, his son Perry said in a statement. He died late Sunday at his home in Wildwood, a St. Louis suburb.

“As my father’s death approached, we had people from all different walks of life share story after story of the personal impact he had on them,” Perry Akin said in a statement to The Associated Press.

“He was a devout Christian, a great father, and a friend to many. We cherish many fond memories from him driving the tractor at our annual hayride, to his riveting delivery of the freedom story at 4th of July parties dressed in the full uniform of a colonial minuteman. The family is thankful for his legacy: a man with a servant’s heart who stood for truth.”

Akin represented a Republican-leaning eastern Missouri district that included St. Louis-area suburbs for 12 years, giving up a safe seat to run for the U.S. Senate in 2012. He emerged from a crowded GOP primary to challenge then incumbent Democratic U.S. Sen. Claire McCaskill, only to seriously hurt Republicans’ chances of recapturing a Senate majority less than two weeks later.

Akin, a strong abortion opponent, was asked during an interview by a St. Louis television station whether he supported allowing abortions for women who have been raped. He answered “from what I understand from doctors” such pregnancies are “really rare.”

He added: “If it’s a legitimate rape, the female body has ways to try to shut that whole thing down.”

His comments sparked an outcry. The Republican presidential candidate, Mitt Romney, immediately rebuked Akin and said his campaign would allow abortions in such cases.

Akin visited the Osage Centre in Cape Girardeau on Sept, 25, 2012, vowing not to quit the race despite pleas by GOP leaders for him to step aside.

On that fall day, six weeks to the day before an election he would lose by a 55% to 39% margin to McCaskill, Akin addressed a crowd of 80 people inside the facility.

“Three weeks ago, I had a bunch of people telling me to quit,” Akin said. “Like any decision, the first thing I thought of was what is the right thing to do (and) when all is said and done, the people of Missouri chose me to do a job — and that is to replace Claire McCaskill.”

According to previous reporting by the Southeast Missourian, Akin lost the financial support of the Republican National Committee, the GOP’s Senate campaign organization and a political action committee affiliated with Republican strategist Karl Rove — eliminating millions of dollars of planned advertising in the Show Me State.

Following the rape remark for which he apologized repeatedly in the waning days of the contest, Akin launched a statewide bus tour and asked for donations to replenish the financially strapped campaign that brought him to Cape Girardeau.

On Twitter Monday, following news of her former opponent’s death, McCaskill released the following statement: “(Akin) was a nice man and although we had major disagreements about just about everything, he was authentic to his beliefs. He actually believed in everything he said, which is a tribute to his character. My thoughts are with his lovely family.”

Criticism of Akin’s remarks clouded his U.S. Senate bid until the end, making him a symbol of how Republicans could fumble away races they had a good chance of winning with a candidate deemed too far to the right. Akin’s campaign initially said he “misspoke,” and Akin later said he was wrong.

Akin faced pressure from the national GOP to withdraw and allow the state party to pick a replacement. He refused and ended up losing the race by nearly 16 percentage points. Yet other Republican officials and officeholders across the U.S. occasionally echoed his remarks — signaling how conservative some of the party’s base had become on the issue.

Two years later, Akin published a book, “Firing Back,” in which he accused GOP leaders of abandoning him and letting McCaskill win and labeling news organizations as bullies. In the book, he also retracted his public apology for his “legitimate rape” remark.

Akin never ran for office again, though early in 2015, he briefly fueled speculation about a 2016 primary challenge to GOP U.S. Sen. Roy Blunt with remarks tea party Republicans wanted “new blood.”

Akin was born July 5, 1947, in New York City, but grew up in the St. Louis area. He received a bachelor’s degree in engineering and management from Worcester Polytechnic Institute in Massachusetts in 1970, served in the U.S. Army and worked for IBM. He worked in corporate management at the St. Louis-based Laclede Steel Co.

He won a seat in the Missouri House in 1988 and served in the Legislature for 10 years. He won Missouri’s 2nd Congressional District seat in 2000 and was reelected five times. He also served on the board of the anti-abortion group Missouri Right to Life.

Republican U.S. Rep. Ann Wagner, who has represented Missouri’s 2nd District since winning election in 2012, said in a statement Akin “was a man of great faith and an unwavering conservative. He was deeply devoted to God, his Country, and Family.”

Another Republican congressman from eastern Missouri, Blaine Luetkemeyer, called Akin “a dedicated husband, father, grandfather and public servant, serving the Show-Me-State for decades at both the state and federal level.”

In the 2012 U.S. Senate primary, Akin faced two formidable opponents, former State Treasurer Sarah Steelman and businessman John Brunner.

Many Democrats thought McCaskill’s best shot at winning reelection would be with Akin as the GOP nominee. Her campaign aired television ads suggesting Akin was too conservative, Brunner was not a reliable conservative and Steelman represented “more politics as usual.”

Republicans took the ads as McCaskill’s attempt to help Akin win the GOP primary. An autobiography McCaskill published in 2015 said she also tried to boost Akin’s campaign by urging it through back channels to resume airing a television ad featuring an endorsement from former conservative GOP presidential candidate and ex-Arkansas Gov. Mike Huckabee.

McCaskill’s moves paid off. Akin prevailed in the eight-person GOP field with only 36% of the vote.

Funeral information has not been announced. Survivors include Akin’s wife, Lulli Boe Akin, his mother, Nancy Bigelow Akin, four sons, two daughters and 18 grandchildren.

Southeast Missourian reporter Jeff Long contributed to this story.

Hanna reported from Topeka, Kansas. Salter reported from O’Fallon, Missouri.