ST. LOUIS -- Eduardo Perez homered with one out in the 11th inning as the St. Louis Cardinals rallied from a five-run deficit to beat the Milwaukee Brewers 6-5 Wednesday night.

Perez hit a 2-2 pitch from Luis Vizcaino (1-0) over the wall in left-center field to give the Cardinals their second straight victory in the three-game series by the same score.

It was the first hit of the season for Perez, who had been 0-for-7 in a reserve role.

Edgar Renteria tied it in the ninth with a two-out, RBI single off Mike DeJean. Renteria's third hit of the game completed the Cardinals' comeback from a 5-0 deficit in the third.

Jason Isringhausen (1-0) worked around leadoff hits in the 10th and 11th for his first victory with the Cardinals, one night after getting his first save. He struck out three in two innings.

Richie Sexson hit a three-run homer, his second, in the first inning for the Brewers.

Rusch also helped himself with an RBI single off the glove of second baseman Placido Polanco in the third.

Sexson, who hit 45 homers last year, entered the game batting .160 before connecting on a belt-high fastball from Andy Benes in the first. Jose Hernandez added an RBI single in the third as the Brewers made it 5-0.

The Cardinals scored three runs in the bottom of the third on J.D. Drew's RBI single, Albert Pujols' grounder that was bobbled by third baseman Tyler Houston for an error and a double-play ball by Marrero. St. Louis cut the gap to a run in the fourth on Drew's two-out RBI single -- the last hit off Rusch.

Benes threw 87 pitches in three-plus innings, allowing five runs on seven hits with four walks. In two starts this season, Benes, who had a 7.38 ERA last year and didn't pitch after Aug. 30, has given up nine runs in seven innings.